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BIOMAGI

 biomagi---logo.jpg

 

 

 

 

Legal Name:  Biomagi, Ltd.

PIC number: 936 254 477

History: Biomagi, Ltd. was composed 23rd March 2010 by prof. RNDr. Andrej Boháč, PhD. who became its CEO.

Chief Executive Officer: prof. RNDr. Andrej Boháč, PhD. (CV-17. August 2016)

Legal Address: Mamateyova 26/1508, 851 04 Bratislava, Slovakia

Bank Address: Tatra banka, Tupolevova 3/a, Bratislava, Slovakia

Bank Account IBAN: SK66 1100 0000 0029 2983 4361

Business Registration Number:  45436819

VAT Number: SK2022999759
EORI Number: SK2022999759

Registration web page: http://www.orsr.sk/hladaj_subjekt.asp?OBMENO=biomagi&PF=0&SID=0&R=on&lan=en

Web page: http://www.mch.estranky.sk/clanky/biomagi.html

Phone: +421 902 522 144

E-mail: andrej.bohac@fns.uniba.sk or biomagi@hotmail.com

Topics: Medicinal chemistry, preclinical drug candidates development, structure based drug design, virtual high throughput screening, drug like filters, target selection and analysis, ligand / protein intermolecular interaction analysis, molecular modelling and lead optimisations, cancer drug candidates and cancer stem cells modulators development (inhibitors of tyrosine kinases VEGFR2, CLK1, TAM TKs, HDAC2 and SMO in Hedgehog pathway), advanced organic synthesis and full spectral compound characterisation (NMR, IR, UV, MS).

No. of full time employees: 3

No. of full time employees in R&D: 2

Annual turnover approx.: 25 000 Euro

Infrastructure: complementary with state-of-the-art for multidisciplinary medicinal chemistry research. There are two laboratories for molecular modelling, equipped with four local workstations and with access to supercomputer centers including large (>1000 CPU) cluster. There is one biological laboratory as well as three laboratories equipped for organic synthesis, including access to high field NMR (300 and 600 MHz), FT UV and IR equipments, high-resolution mass spectroscopy, as well as facility for parallel synthesis and microwave or ultrasound reactions.

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LIST OF PUBLICATIONS AND PATENTS:

Publications:

2017 EJMECH 126, 754–761. link to the paper in EJMECH + PDF + suppl mat + videa DOI: 10.1016/j.ejmech.2016.11.003) M. Murár, J. Dobiaš, P. Šramel, G. Addová, G. Hanquet, A. Boháč; Novel CLK1 Inhibitors Based on N-aryloxazol-2-amine Skeleton - a Possible Way to Dual VEGFR2 TK / CLK Ligands

S.G. Kimani, S. Kumar, V. Davra, Y.-J. Chang, C. Kasikara, K. Geng, W.-I Tsou, S. Wang, M. Hoque, A. Boháč, A. Lewis-Antes, M.S. De Lorenzo, S.V. Kotenko, R.B. Birge Normalization of TAM post-receptor signaling reveals a cell invasive signature for Axl tyrosine kinase 2016 Cell Communication and Signaling, 14, DOI: 10.1186/s12964-016-0142-1. PDF,  The Journal

2017 RCS MedChemComm 8, 81-87 (DOI: 10.1039/c6md00392c, pdf + supplementary info) Deniz Cansen Kahraman, Gilles Hanquet, Loïc Jeanmart, Steve Lanners, Peter Šramel, Andrej Boháč, Rengul Cetin-Atalay; Quinoides and VEGFR2 TKIs influence the fate of hepatocellular carcinoma and its cancer stem cells.
2016 Gen Physiol Biophys 35 511-514, doi: 10.4149/gpb_2015055. 
R. Moravčík, K. Stebelová, A. Boháč, M. Zeman, Inhibition of VEGF mediated post receptor signalling pathways by recently developed tyrosine kinase inhibitor in comparison with sunitinib, pdf

 

 

M. Vojtičková, J. Dobiaš, G. Hanquet, G. Addová, R. Cetin-Atalay, D.C. Yildirim, A. Boháč, Ynamide Click chemistry in development of triazole VEGFR2 TK modulators, 2015 Eur. J. Med. Chem. 103 105-122,
DOI: 10.1016/j.ejmech.2015.08.012

2015 J Het Chem 52 425-39, DOI: 10.1002/jhet.2063
Lucia Lintnerová, Lucia Kováčiková, Gilles Hanquet, Andrej Boháč
Selected Methodologies Convenient for the Synthesis of N,5-Diaryloxazole-2-amine Pharmacophore.

2014 Eur J Med Chem 72, 146-159 DOI:10.1016/j.ejmech.2013.11.023, pdf + supplement mat Lucia Lintnerová, Melissa García-Caballero, Fridrich Gregáň, Milan Melicherčík, Ana R. Quesada, Juraj Dobiaš, Ján Lác, Marta Sališsová, Andrej Boháč A development of chimeric VEGFR2 TK inhibitor based on two ligand conformers from PDB: 1Y6A complex - Medicinal chemistry consequences of a TKs analysis

2013 Beilstein J Org Chem 9, 173-179 DOI:10.3762/bjoc.9.20, pdf, M. Murár, G. Addová, A. Boháč; Synthesis of 5-(ethylsulfonyl)-2-methoxyaniline: An important pharmacological fragment of VEGFR2 and other inhibitors.

2013 Central Eur J Chem 11 502-513 Renata Gašparová, Pavol Koiš, Margita Lácová, Silvia Kováčová, Andrej Boháč Synthesis, reactions and antineoplastic activity of 3-(2-oxo-2H-chromen-3-yl)-2-oxo-2H,5Hpyrano[3,2-c]chromene derivatives


M. Ilić, J. Ilaš, P. Dunkel, P. Mátyus, A. Boháč, S. Liekens, D. Kikelj, Novel 1,4-benzoxazine and 1,4-benzodioxine inhibitors of angiogenesis, 2012 Eur. J. Med. Chem. 58 160-170.

B. Gabajová, D. Valková, A. Boháč, E. Kováčová, R. Moravčík, M. Zeman; hVEGF165 Expression in Escherichia coli Conserves Its Biological Function 2012 J. of Chem. and Chem. Engineering 6 738-743.

M. Remko, A. Boháč, L. Kováčiková; Molecular structure, pKa, lipophilicity, solubility, absorption, polar surface area, and blood brain barrier penetration of some antiangiogenic agents, 2011 Structural Chem. 22 635-648.

S. Kováčová, L. Kováčiková, M. Lácová, A. Boháč, M. Sališová; Microwave assisted one pot synthesis of 7-substituted 2-(2-oxo-2H-chromen-3-yl)acetic acids as precursors of new anti-tumour compounds 2010 Chemical papers 64 806-811.

M. Lácová, R. Gašparová, P. Koiš, A. Boháč, H. M. El-Shaaer; A facile route to phenyl, phenylsulfanyl and phenylselanyl substituted pyrano[3,2-c]chromenes 2010 Tetrahedron 66 1410-1419.

L. Kováčiková, R. Gašparová, A. Boháč, M. Ďurana, M. Lácová; Synthesis of 3-phenyl-2H,5H-pyrano[3,2-c]chromen-2-one derivatives and their antineoplastic activit, 2010 ARKIVOC 11 188-203.

M. Pažický, V. Semak, B. Gášpár, A. Bílešová, M. Sališová, A. Boháč; Efficient synthesis of 2-alkyl-2-hydroxy-6-X-1-tetralones, 2008 ARKIVOC 8 225-241.

V. Semak, A. Boháč, M. Sališová, G. Addová, P. Danko; Preparation of alpha-methyl-gamma-butyrolactone: Mechanism of its formation and utilization in 2-methyl-1-tetralone synthesis, 2008 Chemical papers 62 275-280.

M. Lácová, H. Stankovičová, A. Boháč, B. Kotzianová, Convenient synthesis and unusual reactivity of 2-oxo-2H,5H-pyrano-[3,2-c]chromenes, 2008 Tetrahedron 64 9646-9653.

A. Almássy, Z. Benková, B. Horváth, A. Boháč; Fluxional behavior of methyl-substituted tricarbonyl(tropone)iron complexes and their different reactivity, 2008 J. of Organometal. Chem. 693 3223-3232.

M. Pažický, B. Gášpár, A. Solladié-Cavallo, M. Sališová, A. Boháč, M. Hutta, G. Addová; The epimerization of chiral alpha-amino acids by 2-hydroxy-2-methyl-1-tetralone template - The synthesis, conditions and mechanism of isomerization, 2006 Synthesis – Stuttgart 12 2013-2018.

V. Langer, D. Gyepesová, P. Mach, E. Scholtzová, B. Gášpár, M. Sališová, A. Boháč; Anti-2-Hydroxy-2-methyl-1-tetralone oxime: X-ray and density functional theory study, 2006 Acta Crystallographica Section C-Crystal Structure Communications 62 o199-o202,
URL: http://www.blackwell-synergy.com/doi/full/10.1107/S0108270106005178.

O. Šedý, A. Solladié-Cavallo, M. Sališová, A. Boháč; Organické fosfazénové bázy a ich využitie v organickej chémii 2004 Chemické listy 98 964-969.

L. Soják, G. Addová, R. Kubinec, A. Kraus, A. Boháč; Capillary gas chromatography-mass spectrometry of all 93 acyclic octenes and their identification in fluid catalytic cracked gasoline, 2004 J. of Chromatography A 1025 237-253.

A. Almássy, B. Horváth, A. Boháč, M. Sališová, G. Addová, M. Rosenblum; Thermodynamic and kinetic parameters associated with the fluxional behavior of 2-methyl- and 2,6-dimethyltroponeiron tricarbonylcomplexes 2004 J. of Organometal. Chem. 689 1131-1138.

B. Horváth, A. Boháč, M. Sališová, E. Solčániová, M. Rosenblum; The synthesis of a hydroazulen-2-one skeleton-determination of the diastereoselectivity of [3+2] cycloaddition oftricarbonyl[4,5,6,7-n)-2-methyltropone]iron with E/Z-hapto1-(crotyl)Fp, 2002 J. of Organometal. Chem. 659 43-49.

A. Almássy, M. Pažický, A. Boháč, M. Sališová, G. Addová, M. Rosenblum; Synthesis of 2,6-Dimethyltropone - A New, Convenient Methodology from 2,6-Dimethylcyclohexanone 2002 Synthesis – Stuttgart 12 1695-1700.

G. Addová, L. Soják, R. Kubinec, A. Boháč; The comparison of GC behaviour of acyclic C5-C8 alkenes on squalane and silicone OV-1 stationary phases, 2000 Chemické listy 94 962-963.

R. Kubinec, L. Soják, R. Górová, G. Addová, A. Boháč; The separation of stereoisomers using recycle capillary gas chromatography, 1999 Enantiomer 4 345-350.

A. Boháč, M. Lettrichová, P. Hrnčiar, M. Hutta, Milan; Cyclic beta-diketones - precursors of chiral 1,3-cyclohexadiene iron carbonyl complexes. Ligard exchange - (-)-PPh2(O-HC(Me)-COOEt) - new, chiral, diastereomer-separating ligand in organoiron chemistry, 1996 J. of Organometal. Chem. 507 23-29.

A. Boháč; A transferable gas container (TGC) - improving the balloon inert atmosphere technique, 1995 J. of Chem. Education 72 1995 263-263.

Y. N. Ito, X. Ariza, A. K. Beck, A. Boháč, C. Ganter, R. E. Gawley, F. N. M. Kuhnle, J. Tuleja, Y. M. Wang, D. Seebach; Preparation and structural analysis of several newalpha,alpha,alpha,alpha-tetraaryl-1,3-dioxolane-4,5-dimethanols (TADDOL's) and TADDOL analogs, their evaluation as titanium liganst in the enantioselective addition of methyltitanium and diethylzinc reagents to benzaldehyde, and refinement of the mechanistic hypothesis, 1994 Helvetica Chimica Acta 77 2071-2110.

G. J. Matare, A. Boháč, P. Hrnčiar; Acetylation of beta-Diketone Copper(II) Chelates by Treatment with Ketene 1994 Synthesis – Stuttgart 4 381-382.

A. Boháč, P. Hrnčiar, J. Šraga; Acetylation of 2-acyl-1,3-indandiones with ketene and Determination of the Structure of Products 1992 Chemical papers 46 31-34.

A. Boháč, P. Hrnčiar; 3-Acetoxy-2-cykloalken-1-one by acetylation of cyclic 1,3-diketones with ketene; 1991 Collection of Czechoslovak Chem. Commun. 56 2879-2883.

A. Boháč, P. Hrnčiar; A Convenient Synthesis of 1,3-Diacetoxy-1,3-cycloalkadienes from Cyclic beta-diketones, 1991 Synthesis - Stuttgart. 10 881-882.

A. Boháč, A. Perjéssy, D. Loos, P. Hrnčiar; Elucidation of Acetylation Products of 2-Acyl-1,3-indanediones by Correlation of Infrared Spectral Data, 1991 Monatshefte für Chemie 122 943-948.

 

Patents:

 

Lacova, M.; Bohac, A.; Biologically active compounds with pyrano[3,2-c]chromen-2(5H)-one skeleton and a method of their preparation Slovakia (2011), SK 287542 B6 20110104.

Bohac, A.; Snuparek, V.; Varga, I.; Gattnar, O.; Skoda, A.; Manduch, M. Method of production of trans-tramadol and its salts by epimerization of cis-tramadol Slovakia (2004), SK 284181 B6 20041005.

Veverka, M.; Boháč, A.; Almássy, A.; Addová, G.; Varga, I.; Method of preparation of derivatives of substituted 2-arylalkanoic acids by rearrangement of alpha-haloacetophenones and analogs in the presence of orthoformates and acid catalysts Patent No. WO 2004/046080 A1 – Geneva, World Intellectual Property Organization, 2004.

Veverka, M.; Boháč, A.; Križ, M.; Varga, I.; Method of preparation of terfenadine and its derivatives, Patent No. WO2004/043922 A1. Geneva, World Intellectual Property Organization, 2004.

 

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10th Joint Meeting on Medicinal Chemistry, 25-28 June 2017 Dubrovnik, Croatia venue: Hotel Sheraton in Srebreno (6 km from Dubrovnik)  FLYER
http://www.jmmc2017.hr/

Lecturer: Andrej Boháč, Juraj Dobiaš, Peter Šramel, Miroslav Murár, Matúš Hlaváč (Comenius University, Biomagi, Bratislava, Slovakia)

Plenary lecture: From exceptional kinase conformation to dual kinase inhibitors – chemistry of 2-aminooxazoles